Sophia J. Weber

Dopamine and calcium dynamics in the nucleus accumbens core during food seeking

This study uses calcium and dopamine sensors to examine nucleus accumbens activity during food seeking and extinction-reinstatement paradigms, finding changes in both signals during training and reinstatement.

Persistent vulnerability to heroin relapse across the adult lifespan in rats

This study shows that heroin relapse triggered by drug cues persists for over a year in abstinent rats, indicating long-term vulnerability to opioid relapse.

Distinct prelimbic cortex ensembles encode response execution and inhibition

The paper shows that distinct prelimbic cortex ensembles encode response execution and inhibition during different phases of operant learning in rats.

Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving

This study investigates the role of dopamine transmission at D1 and D2 receptors in the nucleus accumbens in incubated cocaine craving, finding that DA contributes to craving after incubation through postsynaptic changes.

Improved dual-color GRAB sensors for monitoring dopaminergic activity in vivo

The paper develops improved GRABDA sensors to monitor dopaminergic activity in vivo, showing high sensitivity and spatially resolved DA release in mice during behaviors.

MultipleXed Population Selection and Enrichment single nucleus RNA sequencing (XPoSE-seq) enables sample identity retention during transcriptional profiling of rare populations

Incubation of palatable food craving is associated with brain-wide neuronal activation in mice

The paper establishes a mouse model of incubation of palatable food craving and identifies brain-wide activation patterns using whole-brain activity mapping.

SMART: An open source extension of WholeBrain for iDISCO+ LSFM intact mouse brain registration and segmentation

SMART is an open-source R package that extends WholeBrain for registering and segmenting intact mouse brain images to the Allen Brain Institute CCF, with a modified iDISCO+ protocol for Fos labeling.

Incubation of discriminative stimulus-controlled cocaine craving: An animal model relevant to relapse prevention

This study investigates DS-controlled incubation of cocaine craving in rats, finding that cocaine-seeking behavior increases over abstinence, unlike food-seeking behavior.