Laura M. Machesky

Direct targeting of the WAVE-regulatory complex and the actin cytoskeleton by the Anaplasma phagocytophilum effector, AnkA

This study identifies AnkA as a bacterial effector that directly targets the WAVE Regulatory Complex and actin cytoskeleton, using molecular mimicry to subvert host cell functions during infection.

DishCam: an open-source 3D-printed darkfield imager for microbial colonies and small organisms on Petri dishes

DishCam is an open-source 3D-printed darkfield imager for improved imaging of microbial colonies and small organisms on Petri dishes, offering high contrast and compatibility with incubators.

ChemoTrack: A comprehensive dataset linking single-cell migration trajectories to precisely defined chemotactic signals

ChemoTrack provides a large-scale, precise dataset of single-cell migration trajectories linked to chemotactic signals, revealing new insights into how cells respond to chemical gradients.

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.