Jeremy A. Hollis

Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

The SPARK complex forms the molecular basis of vertebrate fertilization

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.