Seiya Oura

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.

This study shows that DCST1 and DCST2 are essential for sperm-egg fusion in mice and zebrafish, with mutations leading to male infertility.

This study shows that Trim41 prevents chaotic X chromosome synapsis in male mice, leading to infertility when disrupted.

The paper identifies KCTD19 as essential for meiotic exit in male mice, showing it interacts with ZFP541 and HDAC1, and its deficiency causes apoptosis during meiosis.