Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.
Giordano de Guglielmo, Lieselot L. G. Carrette, Marsida Kallupi, Molly Brennan, Brent Boomhower, Lisa Maturin, Dana Conlisk, Sharona Sedighim, Lani Tieu, McKenzie J. Fannon, Angelica R. Martinez, Nathan Velarde, Dyar N. Othman, Benjamin C. Sichel, Jarryd Ramborger, , Olivier George
The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.
eLife · Nov 1, 2024Peer-reviewedNeuroscience