Anissia Ait Saada

Canavanine-based assay for gross chromosomal rearrangements reveals genome instability hotspots and modulating genes in fission yeast

Replication fork remodeling proteins, Smc5/6 and Rtt107, promote palindrome-mediated genome instability

The paper identifies a pathway involving Smc5/6 and Rtt107 that promotes palindrome-mediated genome instability through cruciform formation and cleavage.

SUMO protease and proteasome recruitment at the nuclear periphery differently affect replication dynamics at arrested forks.

The paper investigates how SUMO protease and proteasome recruitment at nuclear pores affects replication dynamics at arrested forks in fission yeast.

Deletion of can1/cat1 genes and expression of a dominant any1 mutation establish an effective canavanine selection in fission yeast

This study identifies a dominant any1 mutation that confers strong canavanine resistance in fission yeast, enabling its use as a genetic selection marker.

Histone deposition plays an active role in recombination-dependent replication to balance genome2 stability upon replication stress

The paper shows that histone deposition is essential for completing recombination-dependent replication (RDR) and balancing genome stability during replication stress in fission yeast.

The non-homologous end joining factor Ku orchestrates replication fork resection and fine-tunes Rad51-mediated fork restart

The paper investigates how Ku coordinates fork resection and restart in Schizosaccharomyces pombe, revealing a two-step resection process and the role of Ku in fine-tuning HR-mediated replication restart.