Kirill S. Lobachev

Canavanine-based assay for gross chromosomal rearrangements reveals genome instability hotspots and modulating genes in fission yeast

Replication fork remodeling proteins, Smc5/6 and Rtt107, promote palindrome-mediated genome instability

The paper identifies a pathway involving Smc5/6 and Rtt107 that promotes palindrome-mediated genome instability through cruciform formation and cleavage.

Genetic modifiers of APOBEC-induced mutagenesis

This paper identifies genetic modifiers of APOBEC-induced mutagenesis in yeast and human tumors, revealing factors that influence mutation patterns and DNA repair mechanisms.

Translation in a Box: Orthogonal Evolution in the Saccharomyces cerevisiae Mitochondrion

This paper demonstrates the directed evolution of the Saccharomyces cerevisiae mitochondrial translation system as an orthogonal system to the cytosolic TS, revealing functional dependencies and enabling translation engineering.

Deletion of can1/cat1 genes and expression of a dominant any1 mutation establish an effective canavanine selection in fission yeast

This study identifies a dominant any1 mutation that confers strong canavanine resistance in fission yeast, enabling its use as a genetic selection marker.