Author
Alex B. Costa
Georgia Institute of TechnologyORCID 0000-0001-7166-4240Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 23 mutual co-author links4 papers
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Replication fork remodeling proteins, Smc5/6 and Rtt107, promote palindrome-mediated genome instability
Alex B. Costa, Anissia Ait Saada, Thy Pham, Jiayi Fan, Rebecca Lever, Xiaolan Zhao, Kirill S. Lobachev
The paper identifies a pathway involving Smc5/6 and Rtt107 that promotes palindrome-mediated genome instability through cruciform formation and cleavage.
bioRxiv · May 1, 2026 · PreprintMolecular Biology
Translation in a Box: Orthogonal Evolution in the Saccharomyces cerevisiae Mitochondrion
Brooke Rothschild-Mancinelli, Claudia Álvarez-Carreño, Wenying Guo, Chieri Ito, Alex B. Costa, Anton S. Petrov, Kirill S. Lobachev, Loren Dean Williams
This paper demonstrates the directed evolution of the Saccharomyces cerevisiae mitochondrial translation system as an orthogonal system to the cytosolic TS, revealing functional dependencies and enabling translation engineering.
bioRxiv · Apr 28, 2023 · PreprintSynthetic Biology
Deletion of can1/cat1 genes and expression of a dominant any1 mutation establish an effective canavanine selection in fission yeast
Anissia Ait Saada, Alex B. Costa, Kirill S. Lobachev
This study identifies a dominant any1 mutation that confers strong canavanine resistance in fission yeast, enabling its use as a genetic selection marker.
bioRxiv · Mar 11, 2022 · PreprintGenetics