Johannes Brägelmann

Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

A targetable dependency on nonsense-mediated decay for proteostasis and immune control in small cell lung cancer

This study identifies NMD inhibition as a therapeutic strategy for SCLC by enhancing immunogenicity and improving immunotherapy efficacy through increased neoantigen presentation.

An integrated model of population growth saturation and basal ROS levels predicts cellular ferroptosis sensitivity

The paper models how population growth and ROS levels interact to determine ferroptosis sensitivity, revealing feedback loops and steady states in cellular behavior.

ESM-Effect: An Effective and Efficient Fine-Tuning Framework towards accurate prediction of Mutation's Functional Effect

ESM-Effect is a fine-tuning framework for predicting mutation functional effects, achieving state-of-the-art performance and faster training than multi-modal methods.