Author

Niklas Klümper

University Hospital BonnORCID 0000-0002-3258-0586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Heiko RühliD· 2 shared Johannes OldenburgiD· 2 shared Marieta Ioana TomaiD· 2 shared Michael HölzeliD· 2 shared Tobias BaldiD· 2 shared A. Hartel· 1 shared Aitor AguirreiD· 1 shared Alex A. ZhavoronkoviD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Heiko RühlORCID

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Author profile →

3 papers

Recent·Most cited

Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models

A. Hartel, Anna Stettner, Jacob Mayer, Lea Amina Kalayci, Franziska Schneppenheim, Johannes Oldenburg, Heiko Rühl, Martin Fuhrmann, Tobias Bald, Johannes Brägelmann, Niklas Klümper, Marieta Ioana Toma, Felix Christopher Nebeling, René Hägerling, Michael Hölzel

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

bioRxiv · Jul 17, 2026 · PreprintBioengineering

Evolutionary algorithms accelerate de novo design of potent Nectin-4-specific cancer biologics

Elisabeth Tan, Sophie C Frechen, Bianca Broske, Julia M. Messmer, Tim Noah Kempchen, Benjamin A. McEnroe, Dominic Ferber, Leonie Waluga, Eduard Below, Alexander Hoch, Michelle C.R. Yong, Johannes Oldenburg, Heiko Rühl, Matthias Geyer, Marieta Ioana Toma, , Gregor Hagelueken

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

bioRxiv · Mar 6, 2026 · PreprintBioengineering

Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

Paul Kießling, Mehdi Joodaki, Daryna Pikulska, Emilia Scheidereit, Giulia Cesaro, Mayra Ruiz, Damin Kühn, Kai Peng, Osman Goni, Sebastian Foecking, Samaneh Samiei, Xian Liao, Kai Li, Zihao Feng, Delin Wang, , Christoph Kuppe

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

bioRxiv · Feb 14, 2026 · PreprintGenomics