Lars Bode

Maternal diet and genetics shape the human milk metabolome

This study identifies how maternal diet and genetics influence the human milk metabolome, showing diet explains the most variation and uncovering genetic associations with specific metabolites.

Interactions between human milk components and infant polygenic risk predict childhood atopy

This paper investigates how interactions between infant polygenic risk and maternal human milk components predict childhood atopy, finding that integrating these factors improves prediction accuracy.

A searchable metadata network graph for microbiome metabolomics

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

Human milk components interact with infant genomics to modulate gut microbiota, childhood asthma and atopy

The paper investigates how human milk components interact with infant genomics to affect gut microbiota and risk of childhood asthma and atopy.

Integrated omics analysis reveals human milk oligosaccharide biosynthesis programs in human lactocytes

The paper identifies gene expression patterns and regulatory elements associated with HMO biosynthesis in lactocytes using scRNA-seq and HMO concentration data.

Environmental and Maternal Imprints on Infant Gut Metabolic Programming

The paper examines how environmental and maternal factors influence infant gut metabolism through microbiome and metabolome profiling in Bangladeshi mother-infant pairs.

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria

This study reconstructs carbohydrate utilization pathways in human gut bifidobacteria, revealing strain-specific metabolic capabilities and validating them experimentally.

2'-Fucosyllactose Inhibits Human Norovirus Replication in Human Intestinal Enteroids

This paper shows that 2'-fucosyllactose inhibits replication of a dominant human norovirus strain in intestinal enteroids from adult and pediatric donors.

The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds

The paper creates a spectral library of N-acyl lipids from metabolomics data, identifies novel compounds, and links them to health conditions like HIV and cognitive impairment.

Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome

The paper identifies genetic loci influencing milk gene expression and links these to infant gut microbiome composition in breastfeeding mothers.

Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration

The paper constructs an HMO biosynthesis network using multi-omics integration to predict glycosyltransferases and propose candidate genes for HMO synthesis pathways.

Correcting for sparsity and non-independence in glycomic data through a systems biology framework

The paper introduces GlyCompare, a glycomic analysis method that addresses sparsity and non-independence by leveraging biosynthetic pathways, revealing biological insights in glycoprofiles and human milk oligosaccharides.