Author

Rogerio A. Løbo

Columbia UniversityORCID 0000-0002-1472-8313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dieter M. EgliiD· 2 shared Michael V. ZuccaroiD· 2 shared Adam D. HudginsiD· 1 shared Alejandro De Los AngelesiD· 1 shared Amir Gamliel· 1 shared Bhavini Rana· 1 shared Carl A. MitchelliD· 1 shared Daniela Contreras· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Dieter M. EgliORCID

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3 papers

Recent·Most cited

Low nucleus to cytoplasmic ratio compromises cytokinesis, genome stability and development in haploid embryonic cells

Michael V. Zuccaro, Daniela Georgieva, Shuangyi Xu, Matthew Dennen, Qian Du, Gloryn Chia, Selma Amrane, Lisa C. Grossman, Alejandro De Los Angeles, Robert W. Prosser, Rogerio A. Løbo, Dieter M. Egli

This study shows that a low nucleus-to-cytoplasmic ratio in haploid embryonic cells leads to cytokinesis failure, genome instability, and reduced development.

bioRxiv · Aug 30, 2025 · PreprintCell Biology

The regulatory landscapes of human ovarian ageing

Jin Chen, Xizhe Wang, Adam D. Hudgins, Amir Gamliel, Mingzhuo Pei, Seung-Soo Kim, Daniela Contreras, Jan H.J. Hoeijmakers, Judith Campisi, Rogerio A. Løbo, Zev Williams, Michael G. Rosenfeld, Yousin Suh

This study uses single-nuclei multi-omics analysis to identify molecular and cellular changes in human ovarian ageing and links genetic variants to age at natural menopause.

bioRxiv · May 18, 2022 · PreprintGenomics

Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryos

Michael V. Zuccaro, Jia L. Xu, Carl A. Mitchell, Diego Marín, Raymond Zimmerman, Bhavini Rana, Everett Weinstein, Rebeca T. King, Katherine L. Palmerola, Morgan Elizabeth Smith, Stephen H. Tsang, Robin Goland, Maria Jasin, Rogerio A. Løbo, Nathan R. Treff, Dieter M. Egli

The paper evaluates Cas9-induced repair outcomes at the EYS locus in human embryos, showing microhomology-mediated end joining restores reading frames without mosaicism, while unrepaired breaks lead to chromosome loss.

Cell · Oct 29, 2020Peer-reviewedGenetics