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VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment

This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

Atypical Protein Kinase C iota (PKC{lambda}/{iota}) Ensures Mammalian Development by Establishing the Maternal-Fetal Exchange Interface

This study identifies PKCλ/ι as essential for trophoblast progenitor differentiation into syncytiotrophoblast cells during placentation in both mice and humans.

Trophoblast paracrine signaling regulates placental hematoendothelial niche

This study shows that GATA2 and GATA3 in trophoblast giant cells regulate hematopoietic-angiogenic balance in the placenta through paracrine signaling.