Author

Marc Nazaré

Leibniz-Forschungsinstitut für Molekulare PharmakologieORCID 0000-0002-1602-2330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Adam DowleiD· 1 shared Alan CartmelliD· 1 shared Arne Christian RuferiD· 1 shared Bradley L. HoareiD· 1 shared Charles W.E. TomlinsoniD· 1 shared Chris Taylor· 1 shared Conor J. CrawfordiD· 1 shared David A. SykesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Adam DowleORCID

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2 papers

Recent·Most cited

Structural basis for covalent inhibition of sulfatases by sulfamate warheads

Charles W.E. Tomlinson, Stefano Elli, Morgan E Batiste-Simms, Zongjia Chen, Chris Taylor, Adam Dowle, Edwin Alexander Yates, Marc Nazaré, Martin A. Fascione, Lianne I. Willems, Spencer John Williams, Conor J. Crawford, Alan Cartmell

This paper investigates why aryl sulfatases are inhibited by sulfamate warheads while carbohydrate sulfatases are not, using structural and computational analyses.

bioRxiv · Aug 28, 2026 · PreprintBiochemistry

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay.

Leire Borrega Roman, Bradley L. Hoare, Miroslav Kosar, Roman C. Sarott, Kacper J. Patej, Jara Bouma, Morgan Scott-Dennis, Eline J. Koers, Thais Gazzi, Leonard Mach, Sergio Barrondo, Joan Sallés, Wolfgang Guba, Eric A. Kusznir, Marc Nazaré, , Dmitry B. Veprintsev

This paper develops a TR-FRET-based assay to measure ligand binding kinetics for CB1R and CB2R, finding that D77 enables accurate determination of on- and off-rates for various agonists and antagonists.

Frontiers in Pharmacology · Apr 9, 2025Peer-reviewedPharmacology & Toxicology