Nicolas Skuli

Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment

This study shows that inhibiting glycan degradation prevents HIV-induced inflammation, aging, and cognitive impairment in animal models and human cohorts.

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Increased Expression of ZFPM2 Bypasses SRY to Drive 46,XX Testicular Development: A New Mechanism of 46,XX DSD

This paper identifies increased ZFPM2 dosage as a mechanism for 46,XX testicular development independent of SRY in a mosaic individual.