This study shows that BCL2L13 downregulation in NSCLC promotes metastasis by impairing mitophagy and enhancing epithelial plasticity and anoikis tolerance.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

Shahla Shojaei, Amir Barzegar Behrooz, Kianoosh Naghibzadeh, João Luiz Martins Basso, Javad Alizadeh, Tania Dehesh, Roham Saberi, Bhavya Bhushan, Mehdi Eshraghi, Simone CDS Rosa, Courtney Jessica Clark, Mateusz M. Tomczyk, Laura Cole, Grant Michael Hatch, Vernon Wayne Dolinsky, , Saeid Ghavami

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

bioRxiv · Jan 20, 2026 · PreprintCancer Biology

Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline

Aida Adlimoghaddam, Fariba Fayazbakhsh, Mohsen Mohammadi, Zeinab Babaei, Amir Barzegar Behrooz, Farhad Tabasi, Teng Guan, Iman Beheshti, Mahmoud Aghaei, Daniel J. Klionsky, Benedict C. Albensi, Saeid Ghavami

This study examines sex-specific differences in autophagy and mitophagy in Alzheimer's disease using mouse models and machine learning to predict cellular outcomes.

Cell Death Discovery · Apr 26, 2025Peer-reviewedNeuroscience