Author

Shengxi Guan

New England Biolabs (United States)ORCID 0000-0002-1809-8486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:variant calling· 1

Frequent Co-Authors

Ivan Reis Correa JunioriD· 2 shared Lana SalehiD· 2 shared Mala Samaranayake· 2 shared Nan DaiiD· 2 shared Romualdas Vaisvila· 2 shared Sriharsa PradhaniD· 2 shared Theodore B. Davis· 2 shared Thomas C. EvansiD· 2 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Ivan Reis Correa JuniorORCID

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2 papers

Recent·Most cited

EM-seq: Detection of DNA Methylation at Single Base Resolution from Picograms of DNA

Romualdas Vaisvila, V. K. Chaithanya Ponnaluri, Zhiyi Sun, Bradley W. Langhorst, Lana Saleh, Shengxi Guan, Nan Dai, Matthew A. Campbell, Brittany S. Sexton, Katherine Marks, Mala Samaranayake, James C. Samuelson, Heidi E. Church, Esta Tamanaha, Ivan Reis Correa Junior, , Theodore B. Davis

EM-seq detects DNA methylation at single base resolution using less DNA than bisulfite sequencing, showing improved accuracy and reliability.

Genome Research · Jul 1, 2021Peer-reviewedGenomics

Non-destructive enzymatic deamination enables single molecule long read sequencing for the determination of 5-methylcytosine and 5-hydroxymethylcytosine at single base resolution.

Zhiyi Sun, Romualdas Vaisvila, Laura-Madison Hussong, Bo Yan, Chloé Baum, Lana Saleh, Mala Samaranayake, Shengxi Guan, Nan Dai, Ivan Reis Correa Junior, Sriharsa Pradhan, Theodore B. Davis, Thomas C. Evans, Laurence M. Ettwiller

This paper introduces LR-EM-seq, an enzymatic deamination method for long-range methylation profiling of 5-mC and 5-hmC, achieving better-defined DMRs over 5 kb.

Genome Research · Feb 1, 2021Peer-reviewedGenomics