Jari M. T. Lahti

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

The paper identifies contmeQTLs linking childhood adversity to epigenetic changes in immune cells, which are associated with disease risk and inflammatory profiles.

RAMEN dissects gene-environment contributions to DNA methylome variability in cord blood, finding genetics explains the largest proportion of DNAme variance.

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

This study uses whole genome sequencing to identify 18 novel genetic loci associated with plasma fibrinogen levels, including variants more common in African populations and linked to liver-related traits and disease.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

This study identifies 46 novel genetic loci associated with alcohol consumption and suggests shared genetic mechanisms with neuropsychiatric disorders using GWAS and functional analyses.

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.