Anita Thapar

Genome-wide association study of adolescent-onset depression

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

Rare Maternally Inherited Coding Variants on Chromosome X Carry Predominantly Male Risk in Autism, Tourette Syndrome, and Attention-deficit/Hyperactivity Disorder

Longitudinally stable, brain-based predictive models mediate the relationships between childhood cognition and socio-demographic, psychological and genetic factors

The paper develops brain-based predictive models for childhood cognition using multimodal MRI data from the ABCD study, showing stability over time and partial mediation of socio-demographic, psychological, and genetic factors.

Is genetic liability to ADHD and ASD causally linked to educational attainment?

This paper uses Mendelian randomization to investigate causal links between genetic liability to ADHD/ASD and educational attainment, finding distinct causal effects for ADHD and ASD.

Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: A GWAS meta-analysis

This study identifies 14 genome-wide significant SNPs associated with both ADHD and MDD, revealing novel genetic regions linked to their shared variation.

A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder

This study identifies de novo copy number variants in children with ADHD, finding a higher mutation rate compared to controls and associations with known neurodevelopmental disorder loci.

Using genetics to examine a general liability to childhood psychopathology

The paper examines whether genetic liability to schizophrenia and ADHD contributes to shared risks across childhood psychiatric diagnoses through a general psychopathology factor.

Identifying novel subtypes of irritability using a developmental genetic approach

This paper identifies five irritability trajectory classes in a longitudinal cohort, linking early-onset patterns to ADHD and late-onset patterns to depression, suggesting distinct developmental origins.

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.