Author

Lin Xu

Harold C. Simmons Comprehensive Cancer CenterORCID 0000-0002-2153-4840Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Lin Xu8 papers · The University of Texas Southwestern Medical Center

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alex C. SternishaiD· 1 shared Alexander C.-Y. Tsai· 1 shared Bing QiniD· 1 shared Bing-Mei LiiD· 1 shared Chad A. BrautigamiD· 1 shared Chengyan LiiD· 1 shared Cui-Xia Fan· 1 shared Dailin GaniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperSynthetic Biology

Alex C. SternishaORCID

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3 papers

Recent·Most cited

Niche-dependent epistasis within the cancer genome shapes metastatic fitness

Xiyu Liu, Le He, Min Zhao, Samantha M. Golomb, Wei Ma, Xinrui Yang, Emilija Aleksandrovic, Hazel M. Borges, Kevin M. Dean, Lei Wang, Gary C. Hon, Dailin Gan, Hao Zhu, Jun Li, Lin Xu, Siyuan Zhang

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

bioRxiv · Oct 9, 2026 · PreprintGenetics

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

Alex C. Sternisha, Haocheng Li, Kumar Gajendra, Yi Xiao, Xin Zhao, Jeffrey Isaac Traylor, Lei Guo, Ji Hyung Jun, Morgan Fleishman, Tracey Shipman, Vinesh T. Puliyappadamba, Pranita Kaphle, Qing Ouyang, Michael Schmidt, Diana D. Shi, , Samuel K. McBrayer

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

Science · Jul 16, 2026Peer-reviewedSynthetic Biology

Identification of novel causative genes of childhood epileptic encephalopathies

Yi‐Wu Shi, Jianguo Zhang, Zi-Long Ye, Na He, Wenbin Li, Hankui Liu, Zhi-Gang Liu, Nan-Xiang Shen, Xiao-Chong Qu, Cui-Xia Fan, Jie Wang, Sheng Luo, Yudan Lv, Li Gao, Jing Chen, , Wei‐Ping Liao

The paper identifies three causative genes for childhood epileptic encephalopathies through trio-based whole-exome sequencing and individualized analysis of genetic variants.

medRxiv · Jul 25, 2023 · PreprintGenetic & Genomic Medicine