This study develops and evaluates an HK-fbp1-based vaccine platform against Cryptococcus neoformans, showing superior protection compared to HK-H99 in multiple immunization settings.

bioRxiv · Oct 26, 2026 · PreprintMicrobiology

Mannoprotein Cig1 Contributes to the Immunogenicity of a Heat-Killed F-box Protein Fbp1 Cryptococcus neoformans Vaccine Model

Samantha L. Avina, Siddhi Pawar, Roshni N. Kadam, Amariliz Rivera, Chaoyang Xue

This study identifies Cig1 as an immunogenic antigen in a heat-killed Cryptococcus neoformans vaccine model, showing its role in T cell recruitment and cytokine production.

Infection and Immunity · Nov 28, 2025Peer-reviewedMicrobiology

An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.

Yahui Guo, Mariano A. Aufiero, Kathleen A M Mills, Simon A. Grassmann, Hyunu Kim, Mergim Gjonbalaj, Paul Zumbo, Audrey Billips, Katrina B. Mar, Yao Yu, Laura C. Echeverri Tirado, Lena J. Heung, Amariliz Rivera, Doron Betel, Joseph Chai-Yuen Sun, Tobias M. Hohl

The paper identifies an IFN-STAT1-CYBB axis that mediates protective crosstalk between plasmacytoid dendritic cells and neutrophils during Aspergillus fumigatus infection.

Journal of Clinical Investigation · Aug 5, 2025Peer-reviewedImmunology

Helminth infection favors reprogramming and proliferation of lung neutrophils

Fei Chen, Suheyla B. Batirbek, Vanessa Espinosa, Lianhua Jin, Keyi Wang, Wenhui Wu, William Evan Johnson, Alexander D. Lemenze, Adriana Messyasz, Mark C. Siracusa, Dane Parker, Amariliz Rivera, William C. Gause

This study shows that helminth infection leads to prolonged neutrophil proliferation and survival, distinct from responses to bacterial or fungal infections.

bioRxiv · Mar 25, 2025 · PreprintImmunology