Intracellular acidification by bacteria-derived valeric acid is a mechanism of trans-kingdom ecology against Candida parapsilosis colonization
Keiko Yasuma-Mitobe, Chen Liao, Tibor Németh, Kevin P. Byrne, Audrey Billips, Ruben Jose Jesus Faustino Ramos, Cristine Nicole Salinas, Eric Chan, Martina Perissinoto, Ashley M. Sidebottom, George Plitas, Geraldine Butler, Justin R. Cross, Eric G. Pamer, Attila Gácser, , Tobias M. Hohl
The paper uses machine learning to identify valeric acid as a bacterial metabolite that inhibits Candida parapsilosis growth through intracellular acidification, reducing fungal colonization in mice.
bioRxiv · Sep 12, 2025 · PreprintMicrobiology