Author

Jie Tong

Yale UniversityORCID 0000-0002-8753-0340Unclaimed ORCID profile · follow to get notified of new preprints

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Jie Tong1 paper

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Binfan Chen· 1 shared Bony De KumariD· 1 shared Caihong QiuiD· 1 shared Caroline HendryiD· 1 shared Chao ZhengiD· 1 shared Daniel HoldeniD· 1 shared Garret ManqueniD· 1 shared Gretchen LongiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Binfan Chen

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2 papers

Recent·Most cited

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome

Xiaona Lu, Ying Xie, Youmei Bao, Jiang Yu, Zefeng Wang, Jiali Fan, Wendy C. Sheu, Gretchen Long, Zewei Tu, Jie Tong, Garret Manquen, Yichao Li, Varun Katta, Ryan Dz-Wei Chow, Binfan Chen, , Jiangbing Zhou

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

bioRxiv · Nov 13, 2025 · PreprintGenetics

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16

Chao Zheng, Daniel Holden, Ming‐Qiang Zheng, Richard Pracitto, Kyle C. Wilcox, Marcel Lindemann, Zachary Felchner, Li Zhang, Jie Tong, Krista Fowles, Sjoerd J. Finnema, Nabeel Nabulsi, Richard E. Carson, Yiyun Henry Huang, Zhengxin Cai

This paper develops and evaluates [18F]SDM-16, a metabolically stable SV2A PET tracer, showing high affinity and specific binding in nonhuman primate brains.

European Journal of Nuclear Medicine and Molecular Imaging · Nov 10, 2021Peer-reviewedNeuroscience