This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

Proceedings of the National Academy of Sciences · Jul 13, 2026Peer-reviewedMolecular Biology

PAK1 and NF2/Merlin jointly drive myelination by remodeling actin cytoskeleton in oligodendrocytes

Lucas Baudouin, Noémie Adès, Kadia Kanté, Corinne Bachelin, Hatem Hmidan, Cyrille Deboux, Radmila Panic, Rémy Ben Messaoud, Yoan Velut, Soumia Hamada, Cédric Pionneau, Kévin Duarte, Sandrine Poëa‐Guyon, Jean‐Vianney Barnier, Brahim Nait‐Oumesmar, Lamia Bouslama‐Oueghlani

This study identifies PAK1 and NF2/Merlin as regulators of actin dynamics in oligodendrocytes, showing their role in myelin formation and expansion.

bioRxiv · Oct 16, 2023 · PreprintNeuroscience

PAK3 controls the tangential to radial migration switch of cortical interneurons by coordinating changes in cell shape and polarity

Lucie Viou, Pierre Launay, Véronique Rousseau, Justine Masson, Clarisse Pace, Robert S. Adelstein, X. Ma, Zhengping Jia, Fujio Murakami, Jean‐Vianney Barnier, Christine Métin

This study shows that PAK3 kinase activity regulates the switch from tangential to radial migration in cortical interneurons by affecting cell shape and polarity.

bioRxiv · Jul 6, 2020 · PreprintDevelopmental Biology