Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes
Leire Izagirre‐Urizar, Luna Mora-Huerta, Irene Soler-Sáez, Raquel Morales‐Gallel, María José Ulloa-Navas, Juan Carlos Chara, Stefano Calovi, Cyrille Deboux, Laura Merino‐Cacho, Citlalli Netzahualcoyotzi, Marı́a Domercq, Jose Luis Zugaza, Luc Pellerin, Francisco Garcia‐García, José Manuel García‐Verdugo, , Vanja Tepavčević
This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.
bioRxiv · Jan 10, 2025 · PreprintNeuroscience