Author

Oscar Vargas‐Rodriguez

University of ConnecticutORCID 0000-0002-2301-2800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:protein sequence· 3 Research Focus:protein design· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:multiple species· 1

Frequent Co-Authors

Dieter G. SölliD· 2 shared Jordan DouglasiD· 2 shared Aditya M. KunjapuriD· 1 shared Alanna SchepartziD· 1 shared Alexander A. RadeckiiD· 1 shared Charles W. CarteriD· 1 shared Claudia Álvarez-CarreñoiD· 1 shared Devon A. StorkiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersSynthetic Biology

Dieter G. SöllORCID

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4 papers

Recent·Most cited

Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity

Juan S Maldonado, Stephanie Sepulveda, Sharva Karthikeyan, Karina T. Shirakawa, Ivian Merced, Alexander A. Radecki, Jordan Douglas, Wolfgang Peti, Rebecca Page, Oscar Vargas‐Rodriguez

This study investigates the function, structure, and evolution of CtdA, showing its role in preventing canavanine toxicity in Salmonella and E. coli.

Nucleic Acids Research · Sep 3, 2025Peer-reviewedBiochemistry

AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

Jordan Douglas, Haissi Cui, John J. Perona, Oscar Vargas‐Rodriguez, Henna Tyynismaa, Claudia Álvarez-Carreño, Jiqiang Ling, Lluı́s Ribas de Pouplana, Xiang‐Lei Yang, Michael Ibba, Hubert Becker, Frédéric Fischer, Marie Sissler, Charles W. Carter, Peter R. Wills

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

IUBMB Life · Sep 9, 2024Peer-reviewedBiochemistry

Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons

Jeffery M. Tharp, Oscar Vargas‐Rodriguez, Alanna Schepartz, Dieter G. Söll

The paper demonstrates a triply orthogonal system that reassigns three stop codons to encode three distinct noncanonical amino acids in proteins.

ACS Chemical Biology · Mar 16, 2021Peer-reviewedSynthetic Biology

Engineering post-translational proofreading to discriminate non-standard amino acids

Aditya M. Kunjapur, Devon A. Stork, Erkin Kuru, Oscar Vargas‐Rodriguez, Matthieu Landon, Dieter G. Söll, George McDonald Church

This paper introduces a method called Post-Translational Proofreading (PTP) to improve the accuracy of detecting non-standard amino acid incorporation into proteins by leveraging the N-end rule pathway.

Proceedings of the National Academy of Sciences · Jan 4, 2018Peer-reviewedSynthetic Biology