Author

Leela Phadke

Alzheimer’s Research UK

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Lucy GranatiD· 2 shared Paul John WhitingiD· 2 shared Sarah JollyiD· 2 shared Argyro AlatzaiD· 1 shared Benjamin GaletiD· 1 shared Carmen M. NavarróniD· 1 shared Charles ArberiD· 1 shared Dawn H. W. LauiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Lucy GranatORCID

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2 papers

Recent·Most cited

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Oliver Jonathan Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie‐Claude Potier, John Hardy, Dervis A. M. Salih, Paul John Whiting, , Charles Arber

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

Molecular Neurodegeneration · Jun 20, 2025Peer-reviewedNeuroscience

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

Leela Phadke, Dawn H. W. Lau, Nozie D. Aghaizu, Shania Ibarra, Carmen M. Navarrón, Lucy Granat, Lorenza Magno, Paul John Whiting, Sarah Jolly

This paper develops a triculture model of neurons, astrocytes, and microglia to study glia-neuron interactions and their impact on neuronal activity and synapse function.

Frontiers in Aging Neuroscience · Dec 1, 2022Peer-reviewedNeuroscience