Lucy Granat

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

A Drosophila model of mitochondrial disease phenotypic heterogeneity

This study uses a Drosophila model to show that varying levels of NDUFS1 knockdown lead to distinct phenotypic and metabolic outcomes in complex I deficiency.

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

This study identifies Unkempt as a novel mTORC1 substrate whose phosphorylation regulates cellular morphology by inhibiting its ability to induce bipolar morphology.

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

This paper develops a triculture model of neurons, astrocytes, and microglia to study glia-neuron interactions and their impact on neuronal activity and synapse function.

Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

The paper shows that yeast NDI1 restores metabolite levels, ER-mitochondria contacts, and rescues behavioral and lifespan defects in Drosophila with neuronal complex I deficiency.