Pierre Léopold

Xrp1 integrates cellular stress through different control modes in Drosophila

This study identifies three distinct mechanisms by which Xrp1 is induced in response to different stresses in Drosophila, highlighting its role in the Integrated Stress Response.

Drosophila storage proteins promote both the rate and the duration of tumor growth

This study shows that Drosophila storage proteins, hexamerins, support tumor growth by providing nutrients and inhibiting developmental signals, extending tumor growth duration.

A switch in the mode of tissue growth extends the growth phase of Drosophila wing primordia during early pupal development

This study shows that Drosophila wing discs continue growing during the larva-to-pupa transition and undergo growth arrest later in the pupal period, involving a switch that uncouples proliferation from tissue growth.

A temporal allocation of amino acid resources ensures fitness and body allometry

The paper identifies a two-step mechanism for amino acid storage in Drosophila and shows its impact on organ growth and adult fitness.

An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila

This study identifies an Oatp transporter-mediated steroid sink in Drosophila tumors that promotes cachexia by reducing circulating ecdysone levels and inducing catabolic effects.

A local insulin reservoir ensures developmental progression in condition of nutrient shortage in Drosophila

The paper shows that Dilps are stored in the Corpora Cardiaca and released during nutrient shortage to activate IIS in the prothoracic gland, accelerating pupal development.

Dilp8 controls a time window for tissue size adjustment in Drosophila

This study identifies Dilp8 as a hormone that establishes a time window for tissue size adjustment in Drosophila, ensuring bilateral symmetry by buffering developmental noise.

Inter-organ growth coordination is mediated by the Xrp1/Dilp8 axis in Drosophila

The paper shows that the Xrp1/Dilp8 axis coordinates inter-organ growth in Drosophila by linking organ growth status to systemic responses.