Talin controls the spatial distribution of vinculin tension in focal adhesions
Till Kallem, Yanyu Guo, Meghan K Reynolds, Neil J. Ball, Muktesh Athale, Karen Baker, Vasyl V. Mykuliak, Frans Ek, Silvia Aldaz-Casanova, Paula Turkki, Vesa Pekka Hytönen, Nicholas H. Brown, Brenton D. Hoffman, Jie Yan, Benjamin Thomas Goult
The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.
bioRxiv · May 11, 2026 · PreprintCell Biology