This study shows that chemogenetic degradation of RAF1 in KRAS-driven lung cancer does not replicate genetic ablation outcomes due to scaffold disruption.

bioRxiv · Jul 6, 2026 · PreprintCancer Biology

Extracellular Vesicles from Senescent Tumor Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Valentín Estévez‐Souto, Alex Miralles-Dominguez, Pablo Pedrosa, Patricia Lado‐Fernández, Miguel Angel Prados, Alejandro Failde-Fiestras, Raquel Paredes-Paredes, Jorge Ruz-Ortega, Marı́a José Alonso, Martina Migliavacca, Ester Polo, Rebeca Álvarez, Enrique Vázquez-De Luis, Ana Dopazo, Gabriela N. Condezo, , Sabela Da Silva‐Álvarez

This study shows that extracellular vesicles from senescent tumor cells are both necessary and sufficient to induce paracrine senescence in neighboring cells.

bioRxiv · Mar 27, 2026 · PreprintCancer Biology

Ubiquitin proteomics uncovers RNA polymerase I as a critical target of the Nse1 RING domain

Eva Ibars, Joan Codina-Fabra, Gemma Bellı́, Cèlia Casas, Marc Tarrés, Roger Solé-Soler, Neus P. Lorite, Pilar Ximénez‐Embún, Javier Muñoz, Neus Colomina, Jordi Torres‐Rosell

The paper identifies RNA polymerase I as a target of Nse1's RING domain through ubiquitin proteomics, revealing a role in rDNA segregation.

Cell Reports · May 1, 2023Peer-reviewedMolecular Biology