Jonathan H. Esensten

Automated CAR-T Cell Manufacturing: from Research to Point of Care production.

This paper describes LimCORE, an automated system for CAR-T cell manufacturing that achieves comparable performance to existing methods while reducing operator time.

Performance of a Modular Robotic Cluster Matches Skilled Human Operators for Complex Cell Therapy Manufacturing Tasks

A modular robotic system performs key unit operations in cell therapy manufacturing with accuracy comparable to human operators while ensuring throughput and flexibility.

Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing

The paper develops a non-viral method using hybrid ssDNA repair templates to improve genome engineering in primary human cells, achieving high knock-in efficiency and cell yields for disease modeling and cell therapy.

Reprogramming human T cell function and specificity with non-viral genome targeting

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.