Author

Vivasvan S. Vykunta

Gladstone InstitutesORCID 0000-0002-5409-8635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Alexander MarsoniD· 2 shared Brian Rudolph ShyiD· 2 shared Justin EyquemiD· 2 shared Alexis TalbotiD· 1 shared Allison Grace RothrockiD· 1 shared Alvin S. HaiD· 1 shared Amy C. FaniD· 1 shared Austin W. EdwardsiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersSynthetic Biology

Alexander MarsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Submicron-Sampling of Living Cells by Macrophages

Amy C. Fan, Rukman R. Thota, Nina Kathrin Serwas, Vivasvan S. Vykunta, Kyle Marchuk, Megan K. Ruhland, Lauren Liu, Grace Johnson, Austin W. Edwards, Matthew F. Krummel

This study reveals that macrophages sample living cells through trogocytosis-like mechanisms, leading to distinct antigen processing and differential CD4/CD8 T cell priming.

bioRxiv · Apr 10, 2025 · PreprintImmunology

Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection

Christopher R. Chang, Vivasvan S. Vykunta, Daniel Bryan Goodman, Joseph J. Muldoon, William A. Nyberg, Chang Liu, Vincent Allain, Allison Grace Rothrock, Charlotte H. Wang, Alexander Marson, Brian Rudolph Shy, Justin Eyquem

This paper develops a method to efficiently reprogram T cells at multiple loci using SEED-Selection, achieving high purity for single and combined gene edits.

bioRxiv · Feb 6, 2024 · PreprintSynthetic Biology

Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing

Brian Rudolph Shy, Vivasvan S. Vykunta, Alvin S. Ha, Theodore L. Roth, Alexis Talbot, David N. Nguyen, Yan Yi Chen, Franziska Blaeschke, Shane Vedova, Murad R. Mamedov, Jing-Yi Chung, Hong Li, Jeffrey Lee Wolf, Thomas G Martin, Lumeng Ye, , Alexander Marson

The paper develops a non-viral method using hybrid ssDNA repair templates to improve genome engineering in primary human cells, achieving high knock-in efficiency and cell yields for disease modeling and cell therapy.

bioRxiv · Sep 2, 2021 · PreprintSynthetic Biology