Author

Yongchang Ji

Thermo Fisher Scientific (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alvin S. HaiD· 2 shared Brian Rudolph ShyiD· 2 shared Max Dotson· 2 shared Moloud Ahmadi· 2 shared Nicholas Putnam· 2 shared Nujhat Fatima· 2 shared Prajakta Bhanap· 2 shared Aidan Retherford· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Alvin S. HaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Performance of a Modular Robotic Cluster Matches Skilled Human Operators for Complex Cell Therapy Manufacturing Tasks

Sudeshna Sadhu, Brigitte Schmittlein, Angela Lares, Christopher Cheng, Xiaojie Chen, Varun Bhatia, Winston Zha, Sebastien Wah, Sunaina Nayak, Marco Uboldi, Yifan Yu, Jiawei Wang, Wei Zhang, Prajakta Bhanap, Yongchang Ji, , Jonathan H. Esensten

A modular robotic system performs key unit operations in cell therapy manufacturing with accuracy comparable to human operators while ensuring throughput and flexibility.

International Journal of Pharmaceutics X · Aug 4, 2026Peer-reviewedBioengineering

Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma

Alexis Talbot, K Li, Jae Hyun J. Lee, Shanshan Lang, Chang Liu, Nechama Kalter, Zhongmei Li, Yasaman Mortazavi, Niran Almudhfar, Joseph J. Muldoon, Vincent Allain, William A. Nyberg, Jing-Yi Chung, Charlotte Wang, Zhongxia Qi, , Brian Rudolph Shy

This paper develops a non-viral BCMA CAR-T therapy using CRISPR and 1XX signaling, showing improved safety, potency, and persistence in multiple myeloma.

bioRxiv · May 5, 2026 · PreprintCancer Biology

Ultra-large targeted DNA integrations in primary human cells

Courtney Kernick, Lauren Chow, Mikail Alejandro, Ke Li, Maxwell Gabriel Foisey, Xiaoyu Yang, Claire E. Hilburger, Johnathan Lu, Lujing Wu, Alison K. McClellan, Oliver Takacsi-Nagy, Rocco Brajenovic, Nicole E. Theberath, Emily Celallos Fuentes, Erin Lin, , Theodore L. Roth

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

bioRxiv · Apr 9, 2026 · PreprintGenetics

Accelerating CAR T cell manufacturing with an automated next-day process

Moloud Ahmadi, Nicholas Putnam, Max Dotson, Danny Hayoun, Jasmine Padilla, Nujhat Fatima, Prajakta Bhanap, Gertrude Nonterah, Xavier de Mollerat du Jeu, Yongchang Ji

This study introduces an automated 24-hour CAR T cell manufacturing process that increases naive/stem-cell like T cells and cytotoxic activity, potentially improving therapy efficacy and patient access.

Current Research in Translational Medicine · Dec 7, 2024Peer-reviewedBioengineering