Author

Thomas Kruse

Novo Nordisk FoundationORCID 0000-0002-2619-7388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jakob NilssoniD· 3 shared Blanca Lopez MendeziD· 2 shared Dimitriya Hristoforova Garvanska· 2 shared A. Arockia Jeyaprakash· 1 shared Arminja Nadine KettenbachiD· 1 shared Bob MeeuseniD· 1 shared Brennan C McEwaniD· 1 shared Camilla B. Chan· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

Jakob NilssonORCID

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3 papers

Recent·Most cited

Cell BiologyNature Structural & Molecular BiologyPeer-reviewedMar 1, 2026

A proteome-wide dependency map of protein interaction motifs

Sara M. Ambjørn, Bob Meeusen, Johanna Kliche…·Jakob Nilsson

The paper systematically assesses the function of short linear motifs (SLiMs) by mutating and screening them in human cells, identifying essential SLiMs for cell proliferation and uncovering novel classes and binding partners.

8 citationstop 1%

humanproteomics

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Cell BiologyScience AdvancesPeer-reviewedOct 2, 2024

Substrate recognition principles for the PP2A-B55 protein phosphatase

Thomas Kruse, Dimitriya Hristoforova Garvanska, Julia K. Varga…·Jakob Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

28 citations

protein structuredeep learning

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Cell BiologybioRxivPreprintMay 15, 2018

The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signaling

Gang Zhang, Thomas Kruse, Jakob Nilsson

The paper shows the RZZ complex helps Mad1 bind to Bub1, which is essential for checkpoint signaling, and that this interaction is conserved from yeast to humans.

DOI 10.1101/322834

humanexperimental assay

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