Author

Saef Izzy

Brigham and Women's HospitalORCID 0000-0002-2822-6736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Patrick da SilvaiD· 2 shared Akiko IwasakiiD· 1 shared Alexandra M. NicaiseiD· 1 shared Alva M. CaseyiD· 1 shared Amir Alawi· 1 shared Aryan Rajput· 1 shared Brian J. BacskaiiD· 1 shared Cory M. WillisiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Patrick da SilvaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy

Moustafa Algamal, Shinya Yokomizo, Wadzanai Ndambakuwa, Sarena Abdallah, Maria Virtudes Sanchez-Mico, Rebecca L. Gillani, Patrick da Silva, Aryan Rajput, Lakshita Palanivelu, Yuna Lee, Katy R. Walsh, Sunny Kumar, Kıvılcım Kılıç, Joseph B. El Khoury, Saef Izzy, , Brian J. Bacskai

This study shows anti-Aβ immunotherapy triggers rapid immune-vascular interactions in the leptomeningeal interface, leading to peripheral immune cell adhesion and potentially contributing to ARIA.

bioRxiv · Sep 11, 2026 · PreprintNeuroscience

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice

Peiwen Lu, Saef Izzy, Patrick da Silva, Harm Tjebbe Imkamp, Jonathan R Christenson, Taha Yahya, Maryam Hazim Al Mansi, Amir Alawi, Thaís Garcias Moreira, Michelle Monje, Howard L. Weiner, Akiko Iwasaki

This study shows nasal anti-CD3 antibody treatment reduces neuroinflammation, enhances neurogenesis, and improves cognitive function in a mouse model of Long COVID.

bioRxiv · Apr 16, 2026 · PreprintImmunology

Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance

Joshua D. Bernstock, Cory M. Willis, Monica Emili Garcia‐Segura, Edoardo Gaude, Daniela Anni, Yan-ja Lee, Luke W. Thomas, Alva M. Casey, Nunzio Vicario, Tommaso Leonardi, Alexandra M. Nicaise, Florian A Gessler, Saef Izzy, Mario Buffelli, Jakob Seidlitz, , Luca Peruzzotti‐Jametti

bioRxiv · Mar 29, 2023 · PreprintNeuroscience