Dane Vassiliadis

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper identifies SF3B3 and SF3B5 as a transcription module within the U2 snRNP that regulates Pol II elongation independently of splicing.

The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.

BARtab and bartools provide a scalable pipeline and R package for analyzing synthetic cellular barcodes in genomic and transcriptomic data.

This study benchmarks seven HTO demultiplexing tools using datasets with genetic variant-based ground truth, finding similar performance on high-quality data but poor performance on lower quality data for bimodal distribution methods.