George Howitt

Order Matters: Ambient RNA correction confounds doublet detection in single-cell RNA sequencing

This study shows that ambient RNA correction can reduce doublet detection accuracy and recommends detecting doublets before correction, except when using CellBender.

Menin regulates oncogenic cell identity transcriptional networks in multiple myeloma

This study identifies Menin as a key regulator of oncogenic gene expression in multiple myeloma and shows that Menin inhibitors are effective in myeloma cell lines and models.

SuperCellCyto: enabling efficient analysis of large scale cytometry datasets

SuperCellCyto efficiently analyzes large cytometry datasets by grouping similar cells into supercells, avoiding the need for random subsampling.

Benchmarking single-cell hashtag oligo demultiplexing methods

This study benchmarks seven HTO demultiplexing tools using datasets with genetic variant-based ground truth, finding similar performance on high-quality data but poor performance on lower quality data for bimodal distribution methods.

Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes

The paper uses scRNA-seq and flow cytometry to identify novel immune and epithelial cell populations in preschool CF patients' bronchoalveolar lavage.