Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology
Rashmi Kumari, Christine A Bowen, Upasna Srivastava, Amanda Dabdab Brandelli, Prateek Kumar, Dilpreet Kour, Sneha Malepati, Wooyoung Eric Jang, Mark Bromwich, Hollis Zeng, Anson David Sing, Steven A. Sloan, Heike Wulff, Srikant Rangaraju
This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.
bioRxiv · Dec 25, 2025 · PreprintNeuroscience