Scott P. Lyons

The paper uses cryo-EM to analyze endogenous mGluR2-containing receptor assemblies in mouse brain, revealing distinct structural states and complexes not previously observed in recombinant systems.

The paper investigates whether mGluR2 and 5-HT2A receptors physically interact in vitro or in vivo and finds no evidence for direct interaction or oligomerization.

This study identifies APOE interacting with COX-2 on lipid droplets, showing APOE3 promotes and APOE4 suppresses COX-2 activity and prostaglandin production.

The paper identifies phosphorylation of endomembrane proteins in closed guard cells, suggesting their role in regulating stomatal closure.

The paper examines non-redundant roles of paralogous proteins in yeast glucose-sensing pathways through gene deletion and multi-omics analyses.

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.