Luís A. Vale-Silva

iss-nf: A Nextflow-based end-to-end in situ sequencing decoding workflow

The paper introduces iss-nf, a Nextflow-based workflow for analyzing in situ sequencing data, demonstrating its effectiveness on multiple datasets.

Synthetic chromosome fusion: effects on genome structure and function

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.

Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae

The paper identifies two pathways for meiotic chromosome axis assembly in yeast, showing cohesin-dependent and cohesin-independent mechanisms recruit axis proteins to genomic regions with high gene density.

Topoisomerases modulate the timing of meiotic DNA breakage and chromosome morphogenesis in Saccharomyces cerevisiae

This study investigates the roles of topoisomerases I and II in meiotic DNA breakage and chromosome remodeling in yeast, showing distinct effects of their disruption on DSB timing and chromosome structure.

Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes

The paper identifies privileged end-adjacent regions near telomeres that maintain DSBs and contribute to higher recombination rates on short chromosomes in yeast.

SNP-ChIP: A versatile and tag-free method to quantify changes in protein binding across the genome

SNP-ChIP quantifies changes in protein binding across the genome using intra-species SNPs for normalization, improving between-sample comparisons in ChIP-seq.

Comparative Genomics Of Two Sequential Candida glabrata Clinical Isolates

This study compares the genomes of two sequential C. glabrata clinical isolates to identify mutations associated with azole resistance and host adaptation.