Jamie D. Maziarz

An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

Fetal inflammatory signals regulate maternal investment in a pregnant marsupial

The paper investigates how fetal inflammatory signals in marsupials influence maternal investment, finding that IL-1 and IL-6 inhibition increases fetal biomass but reduces litter survival.

Comparative single cell analysis reveals complex patterns of cell type and cell signaling innovations at the fetal-maternal interface

This paper compares single-cell data across six mammalian species to uncover evolutionary patterns in cell types and signaling at the fetal-maternal interface, finding conserved gene signatures and stepwise evolution of decidual cells.

sc-SPLASH provides ultra-efficient reference-free discovery in barcoded single-cell sequencing

sc-SPLASH enables reference-free discovery in scRNA-seq and spatial transcriptomics, uncovering novel transcriptomic features like V(D)J recombination and secreted repeat proteins.

Hallmarks of uterine receptivity predate placental mammals

This paper compares single-cell transcriptomes of uterine and embryonic tissues across rodents and opossums to show that marsupial uteri activate an ancestral signaling axis similar to eutherian implantation, but with inhibitory signals preventing invasion.

Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossum

The paper compares spermatogenic gene expression in opossum and mouse to identify evolutionary dynamics in germline biology.

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

This study identifies a SNP that affects Wnt4 expression in endometrial stroma, linking it to pregnancy, endometriosis, and reproductive cancers through differential gene regulation.

Proteotype Co-evolution and Diversity in Mammals

The paper quantifies proteomic and phosphoproteomic layers in mammalian fibroblasts to show transcriptome-proteome co-evolution and variability control across species.