BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
Oliver W. Chung, Shun Yao, Ling Wang, Fu Yang, Lauren Schier, Melissa Aldana, Christian G. Cerda-Smith, Haley M. Hutchinson, Kris C. Wood, Weijia Su, Mustafa Khasraw, Lee Zou, Dale A. Ramsden, ZZ Zhao Zhang
This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.
Proceedings of the National Academy of Sciences · Mar 11, 2026Peer-reviewedCancer Biology