Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism
Ashutosh Kumar, Yonghui Zhao, Litao Xie, Rahul Chadda, John D. Tranter, Ryan T. Mikami, Nihil Abraham, Juan Hong, Ethan Yang Feng, David R. Rawnsley, Haiyan Liu, Kayla M. Henry, Gretchen A. Meyer, Meiqin Hu, Haoxing Xu, , Rajan Sah
This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.
Science Advances · Sep 26, 2025Peer-reviewedCell Biology