David W. Raible

A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

Lysosomal ion homeostasis drives delayed hair cell death after aminoglycoside uptake.

This study identifies lysosomal ion homeostasis as a driver of delayed hair cell death caused by aminoglycoside uptake, showing it is independent of ferroptosis.

Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle

The paper shows that retinoic acid and hair cell activity jointly determine spatial patterning in zebrafish utricle hair cells.

Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action

The paper distinguishes two mechanisms of aminoglycoside ototoxicity in zebrafish hair cells based on subcellular localization and timing of cellular responses.

Transdifferentiation is uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear

The paper shows that hair cell regeneration in zebrafish inner ear occurs via transdifferentiation of supporting cells, not through progenitor division.

Proteostasis governs differential temperature sensitivity across embryonic cell types

The paper uses single-cell RNA-seq to study temperature sensitivity in zebrafish embryos, finding that notochord sheath cells are particularly vulnerable due to protein misfolding.

Data-Driven 3D Shape Analysis Reveals Cell Shape-Fate Relationships in Zebrafish Lateral Line Neuromast

The paper uses 3D cell shape analysis in zebrafish neuromasts to identify shape-fate relationships, finding that hair cells have distinct shapes compared to support cells.

Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells

This study identifies Merkel cells in zebrafish, shows their origin and characteristics, and demonstrates their relationship with dermal appendages during skin development.

Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell Subtypes

The paper uses single-cell RNA sequencing to analyze zebrafish inner ear cells, identifying distinct hair cell and supporting cell subtypes and their spatial organization.

Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale

The paper presents single cell transcriptomic data from zebrafish embryos with genetic perturbations to analyze developmental variation and cell type composition.

An in vivo biomarker to characterize ototoxic compounds and novel protective therapeutics

This study introduces a biomarker using fluorescently labeled aminoglycosides in neonatal mice to assess ototoxicity and test protective therapeutics.

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

This study identifies Cachd1 as a novel Wnt receptor-interacting protein essential for left-right neuronal asymmetry in zebrafish.

Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity

This study shows chloroquine reduces hair cells in zebrafish and mouse cochlear cultures, suggesting ototoxicity risks.

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores

The paper identifies two distinct leucophore populations in zebrafish, showing their different origins and functional roles through single-cell transcriptomics and other analyses.

Distinct progenitor populations mediate regeneration in the zebrafish lateral line.

The paper identifies distinct support cell progenitor populations in zebrafish lateral line that differ in their ability to regenerate hair cells and are regulated by Notch signaling.