Laura Colombo

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington disease

Chronic cholesterol delivery via brain-permeable nanoparticles improves cognitive and motor function and reduces mutant Huntingtin aggregates in HD mice.

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles forcholesterol delivery in Huntington disease

This study evaluates hybrid nanoparticles for delivering cholesterol to the brain in Huntington disease, showing improved targeting, controlled release, and therapeutic benefits without inflammation.

Role of misfolded tau in the onset and progression of brain toxicity after trauma

This study shows that misfolded tau from traumatic brain injury induces toxicity in C. elegans, suggesting it drives functional decline rather than just being a marker of neurodegeneration.