Author

Ruud H. M. Wijdeven

Leiden University Medical CenterORCID 0000-0002-3390-7384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abhijeet PataskariD· 1 shared Anna E. GeorgeiD· 1 shared August Smit· 1 shared Bhagyashree S. JoshiiD· 1 shared Birol CabukustaiD· 1 shared Cecilia de HeusiD· 1 shared Chirlmin JooiD· 1 shared Dick W. ZijlmansiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperMolecular Biology

Abhijeet PataskarORCID

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3 papers

Recent·Most cited

The TREM-receptor family interactome in the human brain

Kim de Kleijn, Saskia Weller, Remco V. Klaassen, Frank Koopmans, August Smit, Ruud H. M. Wijdeven

The paper identifies novel interactors of TREML1 and TREML2 using proteomics, highlighting their roles in lipid trafficking and immunity.

bioRxiv · Oct 29, 2026 · PreprintNeuroscience

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion.

Yingjie Zhong, Anna E. George, Roman I. Koning, Nalan Liv, Cecilia de Heus, Rayman T.N. Tjokrodirijo, Manon Messchendorp, Jimmy J.L.L. Akkermans, Birol Cabukusta, George M.C. Janssen, Peter A. van Veelen, Ruud H. M. Wijdeven, Jacques Neefjes, Frederik J. Verweij, Ilana Berlin

The paper identifies MARCKSL1 as a regulator of extracellular vesicle secretion pathways through a CRISPR activation screen and functional studies.

Cell Reports · Jul 31, 2026Peer-reviewedCell Biology

Cell-Surface RNA Forms Ternary Complex with RNA-Binding Proteins and Heparan Sulfate to Recruit Immune Receptors

Zeshi Li, Bhagyashree S. Joshi, Hongbo Yin, Ruud H. M. Wijdeven, Rue A. Koç, Dick W. Zijlmans, Abhijeet Pataskar, Irene Santos‐Barriopedro, Hailiang Mei, Wei Wu, Milad Shademan, Filip M. Zawisza, Eric Bos, Pradeep Chopra, Marvin E. Tanenbaum, , Chirlmin Joo

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

Molecular Cell · Dec 1, 2025Peer-reviewedMolecular Biology