This study uses ex vivo live imaging to observe oocyte formation dynamics in mice, revealing blebbing activity during mitosis-to-meiosis transition and no organelle transfer between germ cells.

The EMBO Journal · Apr 21, 2026Peer-reviewedDevelopmental Biology

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins

Jonathan D. Williams, Valerie M. Tesmer, Sagarika Kannoly, Hiroki Shibuya, Jayakrishnan Nandakumar

The paper develops a data-analysis pipeline for HT-SELEX datasets to study DNA-binding properties of telomeric proteins, showing binding preferences for G-enriched sequences and secondary structures.

bioRxiv · Mar 7, 2026 · PreprintBiochemistry

Intergenerational hormesis is regulated by heritable 18S rRNA methylation

Noa Liberman, M. Hafiz Rothi, Maxim V. Gerashchenko, Christiane Zorbas, Konstantinos Boulias, Fiona G. MacWhinnie, Kejun Ying, Anya Flood Taylor, Joseph Al Haddad, Hiroki Shibuya, Lara Roach, Anna Dong, Scarlett Dellacona, Denis L. J. Lafontaine, Vadim N. Gladyshev, Eric Lieberman Greer

The paper tracks heritable methylation transmission in C. elegans and shows that parental starvation induces intergenerational hormesis via 18S rRNA methylation.

Molecular Cell · Sep 1, 2023Peer-reviewedGenetics

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg fusion

Yonggang Lu, Kentaro Shimada, Jingjing Zhang, Yo Ogawa, Shaogeng Tang, Taichi Noda, Hiroki Shibuya, Masahito Ikawa

This study identifies 1700029I15Rik as a gene critical for the biosynthesis of acrosomal membrane proteins necessary for sperm-egg fusion in mice.

bioRxiv · Apr 15, 2022 · PreprintDevelopmental Biology