Marcus B. Noyes

ZATELLITE: a toolkit to visualize and manipulate human centromeres in live cells using synthetic zinc fingers

ZATELLITE enables real-time visualization and manipulation of human centromeres in live cells using synthetic zinc fingers without causing DNA damage.

Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation

The paper investigates how CTCF mutations affect chromatin accessibility, cohesin binding, and gene regulation through multivariate modeling and mutant perturbations.

Engineered transcription-associated Cas9 targeting in eukaryotic cells

This paper introduces a method to temporally control Cas9 DNA targeting by coupling it with transcription through engineered RNA binding, enabling selective gene editing in yeast and human cells.

Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro .

This study shows that Mint/PDZ domains from non-bilaterian animals bind CaV2 channel C-termini in vitro, suggesting an ancient interaction with evolutionary changes in binding specificity.

Manipulating the 3D organization of the largest synthetic yeast chromosome

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae

The paper develops an optogenetic toolkit for controlling gene expression in yeast by using light to modulate synthetic transcription factors.

A multi-reporter bacterial 2-hybrid assay for the fast, simple, and dynamic assay of PDZ domain - peptide interactions

The paper introduces a bacterial 2-hybrid assay for screening PDZ domain-peptide interactions with improved sensitivity and scalability.