Author

Valérie Dutoit

University of GenevaORCID 0000-0002-3469-4237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Denis MiglioriniiD· 2 shared Alice MachadoiD· 1 shared Audrey Mansuet‐LupoiD· 1 shared Aurélie Thomas· 1 shared Barbara BurroniiD· 1 shared Benita WolfiD· 1 shared Berta MarzaliD· 1 shared Bruno Laugel· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Denis MiglioriniORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Safety profiling of CAR-T cells using an organotypic human tissue platform

Alice Machado, Gary Birsen, Irena Rajnpreht, Izadora Peter Furtado, Salut Colell, Berta Marzal, Maxime Fredon, Kai Ziegler-Martin, Darel Martinez Bedoya, Mattia Fumagalli, Lene Vimeux, Suzel Davanture, Fabien Melchiore, Aurélie Thomas, Mélanie Collet, , Emmanuel Donnadieu

This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.

bioRxiv · Jul 28, 2026 · PreprintImmunology

Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy

Florent Lemaître, Olivier Mercey, Isabelle Méan, Elise Paulin, Valérie Dutoit, Jan A. Rath, Christine Von Gunten, Denis Migliorini, Caroline Arber, Paul Guichard, Virginie Hamel, Benita Wolf

This study uses cryo-expansion microscopy to visualize the nanoscale architecture of immune synapses in T cells and their interactions with tumor cells, revealing structural details of signaling molecules and lytic granules.

Cell Reports · Apr 1, 2026Peer-reviewedImmunology